Depression and long chain n-3 fatty acids in adipose tissue in adults from Crete
G Mamalakis1, N Kalogeropoulos2, N Andrikopoulos2, C Hatzis1, D Kromhout3, J Moschandreas1 and A Kafatos1 1Department of Social Medicine Preventive Medicine and Nutrition, School of Medicine, University of Crete, Iraklion, Crete, Greece; 2Laboratory of Food Chemistry-Biochemistry-Physical Chemistry, Department of Science of Dietetics-Nutrition, Harokopio University, Kallithea, Athens, Greece and 3National Institute for Public Health and the Environment, Nutrition and Consumer Safety Division, Bilthoven, The Netherlands
In conclusion, we observed an inverse relationship between adipose tissue DHA and depression, indicating that a high long-term dietary DHA intake lowers the risk of depression. This is the second report on the relationship between adipose tissue DHA and depression in adults. Given the positive relationship between depression and cytokines, such as IL-1, IL-2, IL-6, INF-g and INF-a, the inverse relationship between DHA and depression, may be the result of an inhibiting effect of the particular fatty acid on cytokine synthesis. Other plausible reasons for this relationship may involve possible stimulatory effects on serotonergic and dopaminergic systems as well as neuroprotection against hippocampal neuronal atrophy and volume loss.