Distribution and Dosing of Omega- 3 Fatty Acids in Humans Linda M.Arterburn,PhD Eileen Bailey- Hall,BS Harry Oken,MD Martek Biosciences Corporation University of Maryland,Baltimore
- DHA is principal n-3 fatty acid in tissues.
- Limited inter- conversion of n-3 FAs.
- ALA not adequate source of LCn-3.
- Plasma response to dietary intake.
- ALA does not accumulate appreciably.
- Dose dependent increases in EPA and DHA.
- Plasma levels equilibrate within 4 wks.
- 2 g DHA/ day gives close to maximal DHA response.
- Tissue levels LCn-3 increase with supplementation.
- Milk DHA levels reflect maternal dietary intake
- Infant DHA levels determined by dietary intake