Erythrocyte fatty acids and breast cancer risk: a case-control study in Shanghai, China
Jackilen Shannon, Irena B King, Rachel Moshofsky, Johanna W Lampe, Dao Li Gao, Roberta M Ray, and David B Thomas
ABSTRACT Background: The role of individual fatty acids in the development and progression of breast cancer is unclear. Although in vitro and animal experiments have supported an inverse association between intake of long chain n3 fatty acids [primarily eicosapentaenoic acid (EPA) and docosahexaenoic acid] and breast cancer risk, findings from population studies are inconsistent. Recent studies have also shown associations between the ratio of saturated to monounsaturated fatty acids (SI) and breast cancer risk. The SI reflects the activity of several genes involved in lipid metabolism, including fatty acid synthase and steroyl coenzyme-A desaturase, that have been shown to be overexpressed in breast cancer.
Conclusion: Our results support a protective effect of n3 fatty acids on breast cancer risk and provide additional evidence for the importance of evaluating the ratio of fatty acids when evaluating diet and breast cancer risk.
Am J Clin Nutr 2007;85:1090 –7.